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임수연 ( Lim Su-Yeon ) - Chonnam National University Hwasun Hospital Department of Nursing
최자윤 ( Choi Ja-Yun ) - Chonnam National University College of Nursing
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Abstract
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Purpose: This study aimed to identify the factors associated with chemotherapy-induced neutropenia (CIN) in diffuse large B-cell lymphoma (DLBCL) patients undergoing combination chemotherapy.
Methods: A total of 111 patients with DLBCL participated in this study at C University Hospital. The CIN group consisted of patients with an absolute neutrophil count (ANC) lower than 1,000 cells/μL. Clinical factors, the level of depression, and the level of healthy lifestyle were measured on the chemotherapy administration day, and the ANC was measured on the next follow-up day.
Results: Binary logistic regression analysis showed that the factors associated with CIN in DLBCL were the presence of B symptoms at diagnosis (β=4.69) and low-risk CIN regimen (β=0.10) among clinical factors, and the level of healthy lifestyle (β=0.17).
Conclusion: Oncology nurses have to focus on the patients vulnerable to CIN having B symptoms at diagnosis, receiving a low-risk CIN regimen, and showing non-adherence to healthy lifestyle practice. Administration of granulocyte colony-stimulating factor can be considered for the patients receiving low-risk CIN regimen to reduce CIN. Education programs including healthy lifestyle practice to improve the immune system should be applied to the DLBCL patients.
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KeyWords
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미만성 거대 B 세포 림프종, 항암화학요법 유발 호중구감소증, 영향요인
Diffuse large B-cell lymphoma, Chemotherapy-induced febrile neutropenia, Precipitating factors
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원문 및 링크아웃 정보
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등재저널 정보
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